Hemodynamic response to induced septic shock and Effect on Prostacyclin and Steroid

Experimental septic shock was produced by giving a suspension of live Escherichia coli intravenously in dogs, confirming the hemodynamic and the biochemical alternations related to shock. The effects of prostacyclin (PGI2) and steroid on hemodynamics in septic shock were evaluated. In conclusion, it was evident that PGI, and/or steroid administration led to an increase in blood flow of the superior mesenteric vein (SMVB) in septic shock in spite of an increase in that of the hepatic artery (HAB) as well as cardiac output (CO) even at short interval. It was defined that tissue perfusion of the liver (HtB) was not improved, reflecting the impairment,of microcirculation in the liver although that of the small bowel (SBtB) was raised. This study, however, lends support to finding that administration of PGI2 and steroid benefits the liver from protection against liver cell damage, keeping on increasing HAB, SMVB, SBtB, and CO even in short term.